Tinjauan Literatur: SUMBER POTENSIAL PENYEBARAN SARS-CoV-2 DARI LINGKUNGAN RUMAH SAKIT DAN PENTINGNYA PEMANTAUAN SANITASI RUMAH SAKIT UNTUK MENEKAN PANDEMI COVID-19 DI INDONESIA

Authors

DOI:

https://doi.org/10.21776/majalahkesehatan.2022.009.03.7

Keywords:

limbah, nosokomial, pandemi, Rumah Sakit, sanitasi

Abstract

Beberapa bukti menunjukkan sumber potensial penyebaran SARS-CoV-2 dari lingkungan rumah sakit. Sanitasi rumah sakit penting untuk mencegah infeksi nosokomial dan menekan penyebaran COVID-19. Telaah literatur ini bertujuan mengidentifikasi potensi bahaya terkait sanitasi serta metode pemantauan sanitasi di rumah sakit selama pandemi COVID-19. Literatur diperoleh dengan menelusuri jurnal dan laporan lembaga resmi luar negeri terkait COVID-19 di internet. Banyak prosedur di rumah sakit yang menghasilkan aerosol, sementara banyak ruangan di rumah sakit belum memenuhi standar ventilasi udara. Di sisi lain, karena penapisan tidak memadai, pegawai rumah sakit dapat bertemu pasien COVID-19 di semua area rumah sakit. Kondisi ini menimbulkan keraguan  akan kebersihan udara dan permukaan benda-benda, serta penyebaran virus antar ruangan di rumah sakit. Identifikasi sanitasi rumah sakit yang sering terlewatkan adalah: 1) kontaminasi virus di udara dan permukaan benda-benda di seluruh area rumah sakit, 2) kontaminasi virus di kasur, bantal, dan guling yang sering terlewatkan pada pembersihan rutin, 3) kontaminasi virus di toilet oleh proses aerosolisasi ekskreta, dan 4) kontaminasi virus di air limbah rumah sakit. Sebaiknya terdapat instansi di setiap kota/kabupaten yang dapat menangani pemeriksaan spesimen lingkungan yang dikumpulkan dari berbagai rumah sakit. Deteksi virus di udara, dapat menggunakan kit deteksi SARS-CoV-2 udara; deteksi permukaan benda, dapat menggunakan swab; pada limbah, dapat digunakan sampel cairan limbah untuk deteksi genom SARS-CoV-2 dengan RT-PCR. Hasil pemeriksaan dapat menjadi panduan untuk mengubah atau mempertahankan aturan dan kebijakan rumah sakit. Kesimpulannya, identifikasi potensi bahaya serta kebutuhan dan metode pemantauan sanitasi rumah sakit harus dikembangkan untuk mencegah infeksi nosokomial COVID-19 dan menekan penyebaran pandemi.

Author Biography

Dian Hasanah, Universitas Brawijaya-RSUD dr. Saiful Anwar Malang

Departemen Fisiologi, Fakultas Kedokteran 

Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran 

References

Coronavirus Disease (COVID-19): How Is It Transmitted?. (Online). Published July 9, 2020. www.who.int. https://www.who.int/news-room/q-a-detail/coronavirus-disease-covid-19-how-is-it-transmitted.

Heller L, Mota CR, Greco DB. COVID-19 Faecal-Oral Transmission: Are We Asking the Right Questions? Science of the Total Environment. 2020; 729:138919. doi:10.1016/j.scitotenv.2020.138919

Mohseni AH, Taghinezhad-S S, Xu Z, Fu X. Body Fluids May Contribute to Human-to-Human Transmission of Severe Acute Respiratory Syndrome Coronavirus 2: Evidence and Practical Experience. Chinese Medicine. 2020; 15:58. doi:10.1186/s13020-020-00337-7.

Allegranzi B, Bagheri Nejad S, Combescure C, et al. Burden of endemic health-care-associated infection in developing countries: systematic review and meta-analysis. Lancet. 2011; 377(9761):228-41. doi: 10.1016/S0140-6736(10)61458-4.

Kementerian Kesehatan Republik Indonesia. (Online). 2003. www.kemkes.go.id. https://www.kemkes.go.id/article/view/502/perkembangan-sars-di-indonesia-tanggal-17-april-2003.html (Accessed November 29, 2020).

Leung NHL, Chu DKW, Shiu EYC, et al. Respiratory Virus Shedding in Exhaled Breath and Efficacy of Face Masks. Nature Medicine. 2020; 26:1–5. doi:10.1038/s41591-020-0843-2.

CDC. Coronavirus Disease 2019 (COVID-19). Centers for Disease Control and Prevention. (Online). Published February 11, 2020. https://www.cdc.gov/coronavirus/2019-ncov/more/scientific-brief-sars-cov-2.html.

ASHRAE Position Document on Infectious Aerosols. (Online). Published 2020. Ashrae.org. https://www.ashrae.org/. (Accessed November 28, 2020).

Transmission Dynamics of COVID-19. The Centre for Evidence-Based Medicine. (Online). http://www.cebm.net/evidence-synthesis/transmission-dynamics-of-covid-19/. (Accessed November 29, 2020).

Jackson T, Deibert D, Wyatt G, et al. Classification of Aerosol-Generating Procedures: a Rapid Systematic Review. BMJ Open Respiratory Research. 2020; 7(1):e000730. doi:10.1136/bmjresp-2020-000730.

Tran K, Cimon K, Severn M, Pessoa-Silva CL, Conly J. Aerosol Generating Procedures and Risk of Transmission of Acute Respiratory Infections to Healthcare Workers: A Systematic Review. PLoS ONE. 2012; 7(4):e35797.

doi:10.1371/journal.pone.0035797.

van Doremalen N, Bushmaker T, Morris DH, et al. Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. New England Journal of Medicine. 2020; 382(16):1564-1567. doi:10.1056/nejmc2004973.

McKinney KR, Gong YY, Lewis TG. Environmental Transmission of SARS at Amoy Gardens. Journal of Environmental and Public Health. 2006; 68(9):26-30.

Eng-kiong Y. Amoy Gardens Investigation Findings Make Public. (Online). Press Release. www.info.gov.hk. https://www.info.gov.hk/gia/general/200304/17/0417247.htm. (Accessed November 29, 2020).

Chin AWH, Chu JTS, Perera MRA, et al. Stability of SARS-CoV-2 in Different Environmental Conditions. (Online). Published online March 18, 2020. doi:10.1101/2020.03.15.20036673.

Goldman E. Exaggerated Risk of Transmission of COVID-19 by Fomites. The Lancet Infectious Diseases. 2020; 20(8):892-893.

doi:10.1016/s1473-3099(20)30561-2

Chatterjee S, Murallidharan JS, Agrawal A, Bhardwaj R. Why Coronavirus Survives Longer on Impermeable than Porous Surfaces. Physics of Fluids. 2021; 33(2):021701. doi: 10.1063/5.0037924

Liu Y, Li T, Deng Y, et al. Stability of SARS-CoV-2 on Environmental Surfaces and in Human Excreta. Journal of Hospital Infection. 2021; 107:105-107. doi:10.1016/j.jhin.2020.10.021.

Mondelli M, Colaneri M, Seminari E, Baldanti F, Bruno R. Low risk of SARS-CoV-2 Transmission by Fomites in Real-Life Conditions. The Lancet Infectious Diseases. 2020; 21(5). doi:10.1016/s1473-3099(20)30678-2.

Jiang F-C, Jiang X-L, Wang Z-G, et al. Detection of Severe Acute Respiratory Syndrome Coronavirus 2 RNA on Surfaces in Quarantine Rooms. Emerging Infectious Diseases. 2020; 26(9):2162-2164. doi:10.3201/eid2609.201435.

Meyerowitz EA, Richterman A, Gandhi RT, Sax PE. Transmission of SARS-CoV-2: A Review of Viral, Host, and Environmental Factors. Annals of Internal Medicine. 2021. doi:10.7326/M20-5008.

Shang J, Wan Y, Luo C, et al. Cell Entry Mechanisms of SARS-CoV-2. Proceedings of the National Academy of Sciences. 2020; 117(21). doi:10.1073/pnas.2003138117.

Meinhardt J, Radke J, Dittmayer C, et al. Olfactory Transmucosal SARS-CoV-2 Invasion as Port of Central Nervous System Entry in COVID-19 Patients. Nat Neurosci. 2021; 24(2):168-175. doi: 10.1038/s41593-020-00758-5. Epub 2020 Nov 30.

Panariello F, Cellini L, Speciani M, De Ronchi D, Atti A. How Does SARS-CoV-2 Affect the Central Nervous System? A Working Hypothesis. Front Psychiatry. 2020;11:582345. doi:10.3389/fpsyt.2020.582345

Cantuti-Castelvetri L, Ojha R, Pedro LD, et al. Neuropilin-1 Facilitates SARS-CoV-2 Cell Entry and Provides a Possible Pathway into the Central Nervous System. Science. 2020; 370(6518):856-860. doi: 10.1126/science.abd2985. Epub 2020 Oct 20.

Zhang H, Li HB, Lyu JR, et al. Specific ACE2 Expression in Small Intestinal Enterocytes May Cause Gastrointestinal Symptoms and Injury After 2019-nCoV Infection. International Journal of Infectious Disease. 2020; 96:19-24.

doi:10.1016/j.ijid.2020.04.027.

Zhou L, Xu Z, Castiglione GM, Soiberman US, Eberhart CG, Duh EJ. ACE2 and TMPRSS2 are Expressed on the Human Ocular Surface, Suggesting Susceptibility to SARS-CoV-2 Infection. The Ocular Surface. 2020; 18(4):537-544.

doi:10.1016/j.jtos.2020.06.007.

Xia J, Tong J, Liu M, Shen Y, Guo D. Evaluation of Coronavirus in Tears and Conjunctival Secretions of Patients with SARS‐CoV‐2 Infection. Journal of Medical Virology. 2020; 92(6):589-594. doi: 10.1002/jmv.25725. Epub 2020 Mar 12.

Wu P, Duan F, Luo C, et al. Characteristics of Ocular Findings of Patients with Coronavirus Disease 2019 (COVID-19) in Hubei Province, China. JAMA Ophthalmology. 2020; 138(5):575-578. doi: 10.1001/jamaophthalmol.2020.1291.

Zeng W, Wang X, Li J, et al. Association of Daily Wear of Eyeglasses with Susceptibility to Coronavirus Disease 2019 Infection. JAMA Ophthalmol. 2020; 138(11):1196-1199. doi:10.1001/jamaophthalmol.2020.3906

Bittmann S. Does COVID-19 Uses ACE-2-Receptors of the Epidermis as Entry into the Body?. Research in Pediatrics & Neonatology. 2020; 4(3). doi:10.31031/rpn.2020.04.000590.

Kam K, Yung CF, Cui L, et al. A Well Infant with Coronavirus Disease 2019 with High Viral Load. Clinical Infectious Diseases. 2020; 71(15):847-849. doi:10.1093/cid/ciaa201

Tellier R, Li Y, Cowling BJ, Tang JW. Recognition of Aerosol Transmission of Infectious Agents: a Commentary. BMC Infectious Diseases. 2019; 19(1). doi:10.1186/s12879-019-3707-y

Chirico F, Sacco A, Bragazzi NL, Magnavita N. Can Air-Conditioning Systems Contribute to the Spread of SARS/MERS/COVID-19 Infection? Insights from a Rapid Review of the Literature. International Journal of Environmental Research and Public Health. 2020; 17(17):6052. doi:10.3390/ijerph17176052.

Qian H, Zheng X. Ventilation Control for Airborne Transmission of Human Exhaled Bio-Aerosols in Buildings. Journal of Thoracic Disease. 2018; 10(Suppl19):S2295–S2304. doi:10.21037/jtd.2018.01.24.

The Centre for Evidence-Based Medicine (CEBM). SARS-CoV-2 Survival in Relation to Temperature and Humidity and Potential for Seasonality. https://www.cebm.net/study/covid-19-sars-cov-2-survival-in-relation-to-temperature-and-humidity-and-potential-for-seasonality/. (Accessed November 30, 2020).

Lu J, Gu J, Li K, et al. COVID-19 Outbreak Associated with Air Conditioning in Restaurant, Guangzhou, China, 2020. Emerg Infect Dis. 2020; 26(7):1628-1631. doi: 10.3201/eid2607.200764. Epub 2020 Apr 2

Arin K. Immediate Action Needed to Avoid Health System Collapse: KCDC. (Online). 2020. The Korea Herald. http://www.koreaherald.com/view.php?ud=20200817000037. (Accessed November 30, 2020).

Qian H, Miao T, Liu L, Zheng X, Luo D, Li Y. Indoor Transmission of SARS‐CoV‐2. Indoor Air. 2021; 31(3):639-645. doi: 10.1111/ina.12766. Epub 2020 Nov 20.

Nishiura H, Oshitani H, Kobayashi T, et al. Closed Environments Facilitate Secondary Transmission of Coronavirus Disease 2019 (COVID-19). (Online). March 3, 2020. MedRXiv. doi:10.1101/2020.02.28.20029272

Xu P, Qian H, Miao T, et al. Transmission Routes of Covid-19 Virus in the Diamond Princess Cruise Ship. (Online). April 14, 2020. MedRXiv.

doi:10.1101/2020.04.09.20059113

Park SY, Kim Y-M, Yi S, et al. Coronavirus Disease Outbreak in Call Center, South Korea. Emerging Infectious Diseases. 2020; 26(8): 1666-1670. doi:10.3201/eid2608.201274.

Jang S, Han SH, Rhee J-Y. Early Release - Cluster of Coronavirus Disease Associated with Fitness Dance Classes, South Korea. Emerging Infectious Diseases Journal. 2020; 26(8). doi:10.3201/eid2608.200633

Hamner L, Dubbel P, Capron I, et al. High SARS-CoV-2 Attack Rate Following Exposure at a Choir Practice — Skagit County, Washington, March 2020. MMWR Morbidity and Mortality Weekly Report. 2020; 69(19):606-610.

doi:10.15585/mmwr.mm6919e6.

Walker J. Boston Biotech’s Meeting Spread Coronavirus as Far as Slovakia and Australia. (Online). August 26, 2020. Wall Street Journal. https://www.wsj.com/articles/boston-biotechs-meeting-spread-coronavirus-as-far-as-slovakia-and-australia-11598394542. (Accessed November 30, 2020).

Horve PF, Dietz L, Fretz M, et al. Identification of SARS-CoV-2 RNA in Healthcare Heating, Ventilation, and Air Conditioning Units. (Online). June 28, 2020. MedRXiv. doi:10.1101/2020.06.26.20141085

Santarpia JL, Rivera DN, Herrera VL, et al. Aerosol and Surface Contamination of SARS-CoV-2 Observed in Quarantine and Isolation Care. Scientific Reports. 2020; 10(1):12732.

doi:10.1038/s41598-020-69286-3

European Centre for Disease Prevention and Control (ECDC). Heating, ventilation and air-conditioning systems in the context of COVID-19: first update. European Centre for Disease Prevention and Control. (Online). 2020.

https://www.ecdc.europa.eu/en/publications-data/heating-ventilation-air-conditioning-systems-covid-19. (Accessed November 29, 2020).

Lange VR. Reusable Hospital Pillows - A Reservoir for Hospital Acquired Pathogens: The Importance of Adequate Decontamination. American Journal of Infection Control. 2014; 42(6):S34-S35.

doi:10.1016/j.ajic.2014.03.097.

Mottar R, Roth M, Allen M, Gerber R, Jeffers BR. Pillow Talk: Examining Pillow Cores in a Regional Burn Center. American Journal of Infection Control. 2006; 34(5):E107-E108.

doi:10.1016/j.ajic.2006.05.078.

Lippmann N, Lübbert C, Kaiser T, Kaisers UX, Rodloff AC. Clinical Epidemiology of Klebsiella pneumoniae Carbapenemases. The Lancet Infectious Diseases. 2014; 14(4):271-272. doi:10.1016/s1473-3099(14)70705-4.

Woodcock AA, Steel N, Moore CB, Howard SJ, Custovic A, Denning DW. Fungal Contamination of Bedding. Allergy. 2006; 61(1):140-142. doi:10.1111/j.1398-9995.2005.00941.x

Jenkins RO, Sherburn RE. Used Cot Mattresses as Potential Reservoirs of Bacterial Infection: Nutrient Availability within Polyurethane Foam. Journal of Applied Microbiology. 2007; 0(0):071203164354001. doi:10.1111/j.1365-2672.2007.03609.x.

Fan J, Gerber PF, Cubas Atienzar A, Eppink L, Wang C, Opriessnig T. Porcine Reproductive and Respiratory Syndrome Virus RNA Detection in Different Matrices under Typical Storage Conditions in the UK. Veterinary Record. 2019; 185(1):21-21.

doi:10.1136/vr.105312.

Konda A, Prakash A, Moss GA, Schmoldt M, Grant GD, Guha S. Aerosol Filtration Efficiency of Common Fabrics Used in Respiratory Cloth Masks. ACS Nano. 2020; 14(5):6339–6347. doi:10.1021/acsnano.0c03252.

Jiang F-C, Jiang X-L, Wang Z-G, et al. Detection of Severe Acute Respiratory Syndrome Coronavirus 2 RNA on Surfaces in Quarantine Rooms. Emerging Infectious Diseases. 2020; 26(9):2162-2164. doi:10.3201/eid2609.201435.

Sedlmaier N, Hoppenheidt K, Krist H, Lehmann S, Lang H, Büttner M. Generation of Avian Influenza Virus (AIV) contaminated Fecal Fine Particulate Matter (PM2.5): Genome and Infectivity Detection and Calculation of Immission. Veterinary Microbiology. 2009; 139(1-2):156-164. doi:10.1016/j.vetmic.2009.05.005.

Lai MYY, Cheng PKC, Lim WWL. Survival of Severe Acute Respiratory Syndrome Coronavirus. Clinical Infectious Diseases. 2005; 41(7):e67-e71. doi:10.1086/433186.

Wölfel R, Corman VM, Guggemos W, et al. Virological Assessment of Hospitalized Patients with COVID-2019. Nature. 2020; 581:465–469. doi:10.1038/s41586-020-2196-x

Lescure F-X, Bouadma L, Nguyen D, et al. Clinical and Virological Data of the First Cases of COVID-19 in Europe: a Case Series. The Lancet Infectious Diseases. 2020; 2(6):697-706. doi:10.1016/S1473-3099(20)30200-0.

Holshue ML, DeBolt C, Lindquist S, et al. First Case of 2019 Novel Coronavirus in the United States. New England Journal of Medicine. 2020; 382:929-936. doi:10.1056/nejmoa2001191.

Xiao F, Tang M, Zheng X, Liu Y, Li X, Shan H. Evidence for Gastrointestinal Infection of SARS-CoV-2. Gastroenterology. 2020; 158(6): 1831–1833.e3. doi:10.1053/j.gastro.2020.02.055

McDermott CV, Alicic RZ, Harden N, Cox EJ, Scanlan JM. Put a Lid on It: Are Faecal Bio-Aerosols a Route of Transmission for SARS-CoV-2? Journal of Hospital Infection. 2020; 105(3):397-398. doi:10.1016/j.jhin.2020.04.024

Cipriano M, Ruberti E, Giacalone A. Gastrointestinal Infection Could Be New Focus for Coronavirus Diagnosis. Cureus. 2020; 12(3):e7422. doi:10.7759/cureus.7422.

Knowlton SD, Boles CL, Perencevich EN, Diekema DJ, Nonnenmann MW. Bioaerosol Concentrations Generated from Toilet Flushing in a Hospital-Based Patient Care Setting. Antimicrobial Resistance & Infection Control. 2018; 7(16). doi:10.1186/s13756-018-0301-9.

Tang S, Mao Y, Jones RM, et al. Aerosol Transmission of SARS-CoV-2? Evidence, Prevention and Control. Environment International. 2020; 144:106039. doi:10.1016/j.envint.2020.106039

Gormley M, Aspray TJ, Kelly DA, Rodriguez-Gil C. Pathogen Cross-Transmission Via Building Sanitary Plumbing Systems in a Full Scale Pilot Test-Rig. PLoS ONE. 2017;1-13. doi:10.1371/journal.pone.0171556

Gundy PM, Gerba CP, Pepper IL. Survival of Coronaviruses in Water and Wastewater. Food and Environmental Virology. 2008; 1(1). 10. doi:10.1007/s12560-008-9001-6

Gu J, Han B, Wang J. COVID-19: Gastrointestinal Manifestations and Potential Fecal–Oral Transmission. Gastroenterology. 2020;158:1518–1519. doi: 10.1053/j.gastro.2020.02.054.

Xu J, Zhao S, Teng T, Abdalla AE, Zhu W, Xie L, Wang Y, Guo X. Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV. Viruses. 2020; 12:244. doi: 10.3390/v12020244.

Gertjan M, Heijnen L, Elsinga G, Ronald I, Brouwer A. Presence of SARS-Coronavirus-2 RNA in Sewage and Correlation with Reported COVID-19 Prevalence in the Early Stage of the Epidemic in The Netherlands. Environ Sci Technol Lett. 2020; 7(7):511–516. doi: 10.1101/2020.03.29.20045880.

CSIRO. Monitoring Wastewater. (Online). 2020. https://www.csiro.au/en/Research/Health/Infectious-diseases-coronavirus/Understanding-the-spread/Monitoring-wastewater. (Accessed November 30, 2020).

Chavarria-Miró G, Anfruns-Estrada E, Guix S, et al. Sentinel Surveillance of SARS-CoV-2 in Wastewater Anticipates the Occurrence of COVID-19 Cases. MedRXiv. 2020. doi:10.1101/2020.06.13.20129627.

Hsu J. How the COVID-19 Pandemic May Reshape US Hospital Design. (Online). 2020. https://www.medscape.com/viewarticle/928952. (Accessed August 20, 2020).

Atkinson J, Chartier Y, Lúcia Pessoa-Silva C, Jensen P, Li Y, Seto H (Editors). Natural Ventilation for Infection Control in Health-Care Settings. WHO Press. (Online). 2009.

https://www.who.int/water_sanitation_health/publications/natural_ventilation.pdf.

Sireesha NL. Correlation amongst Indoor Air Quality, Ventilation and Carbon Dioxide. Journal of Scientific Research. 2017; 9(179). doi: 10.3329/jsr.v9i2.31107.

Buising K, Schofield R, Irving L, et al. Use of Portable Air Cleaners to Reduce Aerosol Transmission on a Hospital COVID-19 Ward. Infect Control Hosp Epidemiol. 2021: 24:1-6. doi:10.1101/2021.03.29.21254590.

World Health Organization (WHO). Water, Sanitation, Hygiene, and Waste Management for the COVID-19 Virus. (Online). 2020. https://apps.who.int/iris/bitstream/handle/10665/331846/WHO-2019-nCoV-IPC_WASH-2020.3-eng.pdf. (Accessed December 4, 2020).

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09-11-2022

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Hasanah, D. (2022). Tinjauan Literatur: SUMBER POTENSIAL PENYEBARAN SARS-CoV-2 DARI LINGKUNGAN RUMAH SAKIT DAN PENTINGNYA PEMANTAUAN SANITASI RUMAH SAKIT UNTUK MENEKAN PANDEMI COVID-19 DI INDONESIA. Majalah Kesehatan, 9(3), 181–198. https://doi.org/10.21776/majalahkesehatan.2022.009.03.7

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Original Research Article